Inhibitory effects of diesel exhaust components and flavonoids on 20α-hydroxysteroid dehydrogenase activity in mouse tissues
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The inhibitory effects of diesel exhaust components and flavonoids on20α-hydroxysteroid dehydrogenase (20α-HSD) activity were examined in cytosolicfractions from the liver, kidney and lung of male mice. 9,10-Phenanthrenequinone(9,10-PQ) and 1,2-naphthoquinone (1,2-NQ), which are contained in diesel exhaustparticles (DEPs), potently inhibited 20α-HSD activity in liver cytosol. 9,10-PQ alsoinhibited the enzyme activity in lung cytosol. However, 20α-HSD activity in kidneycytosol was little inhibited by 9,10-PQ or 1,2-NQ. Flavonoids such as quercetin,fisetin and kaempferol exhibited high inhibitory potencies for 20α-HSD activity in livercytosol, whereas these flavonoids were poor inhibitors for the enzyme activity in kidneycytosol. It is likely that several diesel exhaust components and flavonoids augment thesignaling of progesterone in the liver cells, by inhibiting potently 20α-HSD activity inmouse liver cytosol. The possibility that there are distinct enzymes catalyzing20α-HSD activity in non-reproductive tissues of male mice is also discussed.
- Informa Healthcareの論文
- 2007-08-00
Informa Healthcare | 論文
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