Role of oxidative DNA damage in dietary carcinogenesis
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概要
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Dietary factors are implicated in approximately 35% ofcancers attributed to environmental factors. Although an extremely wide variety of dietary factors are considered to contribute to carcinogenesis，its precise mechanismremains to be clarified. We focused on the role of oxidative DNA damage in carcinogenesis mediated by variousdietary factors. We investigated the mechanism of oxidative DNA damage induced by a) amino acid metabolites，in relation to carcinogenesis caused by protein intakeand amino acid imbalance，b) heterocyclic amines formed during cooking meat and fish，c) sugar and hyperglycemiarelated aldehydes，d) carcinogens contained in fermented foods，such as urethane，e) phytoestrogens including soy isoflavones，f) carcinogens in edible plants，such as caffeic acid and isothiocyanate，g) food additives，such as potassium bromate and benzoyl peroxide. These dietary factors and their metabolites induced metal-mediated oxidative damage to DNA in human cultured cells and 32P-labeledDNA fragments obtained from human cancer-relevant genes. On the basis of our results，it is concluded that polycyclic compounds， such as heterocyclic amines，can cause oxidative DNA damage，although they appear tomainly form DNA adduct. On the other hand， monocyclic and aliphatic compounds，such as amino acid metabolites and urethane，may mainly cause oxidative DNA damage whereas they do not appear to form DNA adduct. Soyisoflavones may cause carcinogenesis through initiation via oxidative DNA damage caused by their metabolites and promotion via cell proliferation induced by themselves. Inthis review，we discuss the role of oxidative DNA damage as the common mechanism of dietary carcinogenesis.Dietary factors are implicated in approximately 35% of cancers attributed to environmental factors. Although an extremely wide variety of dietary factors are considered to contribute to carcinogenesis, its precise mechanism remains to be clarified. We focused on the role of oxidative DNA damage in carcinogenesis mediated by various dietary factors. We investigated the mechanism of oxidative DNA damage induced by a) amino acid metabolites, in relation to carcinogenesis caused by protein intake and amino acid imbalance, b) heterocyclic amines formed during cooking meat and fish, c) sugar and hyperglycemia-related aldehydes, d) carcinogens contained in fermented foods, such as urethane, e) phytoestrogens including soy isoflavones, f) carcinogens in edible plants, such as caffeic acid and isothiocyanate, g) food additives, such as potassium bromate and benzoyl peroxide. These dietary factors and their metabolites induced metal-mediated oxidative damage to DNA in human cultured cells and ^<32>P-labeled DNA fragments obtained from human cancer-relevant genes. On the basis of our results, it is concluded that polycyclic compounds, such as heterocyclic amines, can cause oxidative DNA damage, although they appear to mainly form DNA adduct. On the other hand, monocyclic and aliphatic compounds, such as amino acid metabolites and urethane, may mainly cause oxidative DNA damage whereas they do not appear to form DNA adduct. Soy isoflavones may cause carcinogenesis through initiation via oxidative DNA damage caused by their metabolites and promotion via cell proliferation induced by themselves. In this review, we discuss the role of oxidative DNA damage as the common mechanism of dietary carcinogenesis.
- 日本環境変異原学会の論文
- 2006-11-30
日本環境変異原学会 | 論文
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