On The Chemical Nature of Vitamin D
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1. Vegetable oils after irradiation with ultra-violet rays were less readily hydrolysed by the castor-bean lipase than were the original and the greater the iodine value the greater was the influence of irradiation, and the decrease in the enzymic hydrolysis-velocity of oil is directly proportional to the length of time of irradiation. There existed a certain correlation between the iodine value of vegetable oil and its enzymic hydrolysis-velocity; namely, the greater the iodine value the less was the velocity and from this fact the nutritive value of fat and oil was assumed to be inversely proportional to its iodine value. The viscosity of vegetable oil ran parallel with its enzymic hydrolysis-velocity; namely, the greater the viscosity the greater was the velocity. 2. The action of ultra-violet rays which decrease the enzymic hydrolysis-velocity of vegetable oils, increase the acid value and the viscosity, and decrease the iodine value of the oils, was nothing but the action of ozone, and the ultra-violet rays corresponded to an ozonegenerator when seen from the viewpoint of enzymology. 3. The action of ozone upon cholesterol and oil was closely analogous to that of ultra-violet rays as regards photoactivity, colour reactions, etc. 4. Ozone exerted some definite curative action on rickets in rats on the rachitogenic diet when the rickety rats were fed in an ozonized atmosphere. 5. Ergosterol was activated antirachitically after the appropriate action of ozone. 6. The rate of activation of ergosterol after the action of ozone increased gradually and then a maximum point of potency was reached but thereafter the further action caused a falling off in potency, the product becoming inactive at last. 7. Under my experimental conditions, a daily dose 0.1 mg. and 0.05 mg. of ergosterol ozonized for 3 minutes was sufficient to heal rickets completely and a daily dose 0.015 mg. was somewhat efficacious. Ergosterol ozonized for 0.5 minutes was not efficacious and ergosterol ozonized for 6 minutes prevented even in a daily dose 0.1 mg. in both cases. 8. It was suggested from my experimentaI results that Δ1 mono-ozonide ergosterol will possibly be vitamin D. And also it was roughly concluded such that the imperfectly ozonized ergosterol is vitamin D.
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