Bornavirus closely associates and segregates with host chromosomes to ensure persistent intranuclear infection.
スポンサーリンク
概要
- 論文の詳細を見る
Bornaviruses are nonsegmented negative-strand RNA viruses that establish a persistent infection in the nucleus and occasionally integrate a DNA genome copy into the host chromosomal DNA. However, how these viruses achieve intranuclear infection remains unclear. We show that Borna disease virus (BDV), a mammalian bornavirus, closely associates with the cellular chromosome to ensure intranuclear infection. BDV generates viral factories within the nucleus using host chromatin as a scaffold. In addition, the viral ribonucleoprotein (RNP) interacts directly with the host chromosome throughout the cell cycle, using core histones as a docking platform. HMGB1, a host chromatin-remodeling DNA architectural protein, is required to stabilize RNP on chromosomes and for efficient BDV RNA transcription in the nucleus. During metaphase, the association of RNP with mitotic chromosomes allows the viral RNA to segregate into daughter cells and ensure persistent infection. Thus, bornaviruses likely evolved a chromosome-dependent life cycle to achieve stable intranuclear infection.
- 2012-05-17
論文 | ランダム
- 畑輪作における前後作組合わせ様式に関する研究-2-
- 畑輪作における前後作組合せ様式に関する研究-1-
- 大豆育種における選抜に関する実験的研究
- 大豆種子の熟度と発芽能力との関係
- 大豆の感温性,感光性に関する研究-2-