Basosquamous carcinoma with systemic metastasis in a miniature Pinscher

概要

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Basosquamous carcinoma (BSCC) is a rare malignancy, primarily composed of basal cellswith foci of squamous differentiation. It is considered to be histologically an intermediatetype between basal cell carcinoma and squamous cell carcinoma, and is known to haveaggressive behaviors. BSCC occurred in a 17-year-old female minipin with a history ofsurgical excision for a mammary tumor. The right upper hindlimb was severely enlarged to8 × 5 cm. Cross-section showed a homogenous white to yellow-white mass compressing thesurrounding muscular tissues. The tumor metastasized also to the lungs, heart, abdominalcavity, liver and salivary gland. Microscopically, basaloid cells were crowded into solidnests or lobules separated by well-developed fibrous tissues with occasional keratinizations.Since there was no skin lesions, the tumor is assumed to be originated from the formerlypresent tumor in mammary gland. To our literature review, this case is the first BSCC withsystemic metastasis in a dog.