2-(p-Nitrophenyl)-2′-deoxyadenosine, a new type of mutagenic nucleoside

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概要

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• A crude preparation of 2-phenyladenosine was found to be mutagenlc in the Ames Salmonella assay. In the purification of this preparation, it was revealed that 2-phenyladenosine itself was nonmutagenic but that 2-(m- and p-nitrophenyl)-adenosines (5m,p) contaminating the sample were the mutagenic principles. A structure-activity relationship study was carried out, and it was found that 5p, 2-(p-nitrophenyl)- adenine (7p), and 2-(p-nitrophenyl)-2′-deoxyadenosine (15p) were strongly mutagenic toward S. typhimurium TA98 and TA100 without metabolic activation, the potency being in the order 15p > 7p > 5p. The potency of 15p in TA98 was one order of magnitude greater than that of 4-nitroquinoline N-oxide. 15p also showed mutagenicity in the mouse cell line FM3A in culture.

• Oxford University Pressの論文

著者

• Negishi Kazuo

  Nihon Pharmaceutical University

関連論文

• Bisulfite-mediated Deamination of Cytosine in DNA under Near-neutral Conditions
• 2-(p-Nitrophenyl)-2′-deoxyadenosine, a new type of mutagenic nucleoside

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