Depigmenting mechanism of NSAIDs on B16F1 melanoma cells

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概要

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• The aim of the present work was to clarify the anti-melanogenic mechanism of non-steroidal anti-inflammatory drugs (NSAIDs). Mefenamic acid, diclofenac, and nimesulide were used in this study, and these drugs inhibit melanin synthesis in B16F1 melanoma cells. To elucidate the anti-melanogenic mechanism of NSAIDs, we performed western blotting analysis for melanogenic proteins, such as tyrosinase, TRP-1, and TRP-2. All NSAIDs used in this study inhibited tyrosinase protein level. Semi-quantitative RT-PCR analysis showed that the depigmentation effect of mefenamic acid and nimesulide might be due to the inhibition of tyrosinase gene transcription. These results indicate that NSAIDs inhibit α-MSH-enhanced melanin synthesis, and are candidate anti-melanogenic agents since they might be effective in hyperpigmentation disorders.

著者

• Sato Kazuomi

  静岡大学 農学部応用生物化学

• Toriyama Masaru

  静岡大学 農学部応用生物化学

関連論文

• Depigmenting Mechanisms of All-Trans Retinoic Acid and Retinol on B16 Melanoma Cells
• Down-Regulation of Tyrosinase Expression by Acetylsalicylic Acid in Murine B16 Melanoma(Molecular and Cell Biology)
• Depigmenting Mechanisms of All-Trans Retinoic Acid and Retinol on B16 Melanoma Cells
• Depigmenting mechanism of NSAIDs on B16F1 melanoma cells

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