Three-dimensional craniomaxillary characteristics of the mouse with spontaneous malocclusion using micro-computed tomography

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The aim of this study was to clarify the morphological characteristics of cranio-maxillary deviations in BALB/c-bm/bm mice with a spontaneous malocclusion (incisal transverse crossbite) using three-dimensional (3D) morphological measurements. Sixty female mice aged 13 and 25 weeks were divided into the following groups: control (BALB/c-+/+ mice, n = 20), Norm (BALB/c-bm/bm mice with a normal occlusion, n = 20), and Mal (BALB/c-bm/bm mice with a malocclusion, n = 20). Various points in the skull were selected and the distances between two points were measured using images of 3D micro-computed tomography (CT). At both ages, the lengths of almost all measurements in the Norm and Mal groups were significantly shorter than those in the control group. Comparison between the shifted and non-shifted sides in the Mal group showed that significant lateral deviation at the maxilla and nasal bone had occurred. Statistically significant differences in measurement values among the three groups were evaluated by one-way analysis of variance (ANOVA) with a probability level of P <0.05 considered statistically significant. Using 3D micro-CT images, the results of this study quantitatively showed that the cranio-maxillary complex of BALB/c-bm/bm mice is significantly smaller than that of BALB/c-+/+ mice and that BALB/c-bm/bm mice have a spontaneous transverse crossbite due to lateral deviation of the maxilla and nasal bone.
Oxford University Pressの論文