Analysis of Reactive Oxygen Metabolites (ROMs) after Cardiovascular Surgery as a Marker of Oxidative Stress
スポンサーリンク
概要
- 論文の詳細を見る
The transient systemic low perfusion that occurs during cardiovascular surgery leads to oxidative stress and the production of free radicals. A systemic increase of various markers of oxidative stress has been shown to occur during cardiopulmonary bypass (CPB). However, these markers have not been adequately evaluated because they seem to be reactive and short-lived. Here, oxidative stress was measured using the free radical analytical system (FRAS 4) assessing the derivatives of reactive oxygen metabolites (d-ROMs) and biological antioxidant potential (BAP). Blood samples were taken from 21 patients undergoing elective cardiovascular surgery. CPB was used in 15 patients, and abdominal aortic aneurysm (AAA) surgery without CPB was performed in 6. Measurements of d-ROMs and BAP were taken before surgery, 1 day, 1 week, and 2 weeks after surgery, and oxidative stress was evaluated. The d-ROM level increased gradually after cardiovascular surgery up to 2 weeks. Over time, the d-ROM level after surgery involving CPB became higher than that after AAA surgery. This difference reached statistical significance at 1 week and lasted to 2 weeks. The prolongation of CPB was prone to elevate the d-ROM level whereas the duration of the aortic clamp in AAA surgery had no relation to the d-ROM level. The BAP was also elevated after surgery, and was positively correlated with the level of d-ROMs. In this study, patients who underwent cardiovascular surgery involving CPB had significant oxidative damage. The production of ROMs was shown to depend on the duration of CPB. Damage can be reduced if CPB is avoided. When CPB must be used, shortening the CPB time may be effective in reducing oxidative stress.
著者
-
Tanemoto K
Division Of Thoracic And Cardiovascular Surgery Department Of Surgery Kawasaki Medical School
-
Masaki Hisao
Department Of Cardiovascular Surgery Kawasaki Medical School
関連論文
- Analysis of Reactive Oxygen Metabolites (ROMs) after Cardiovascular Surgery as a Marker of Oxidative Stress
- A case of simultaneous lung cancer and abdominal aortic aneurysm treated with a two-stage strategy
- Papillary Fibroelastoma Developing from the Left Ventricular Septum
- Pure Red Cell Aplasia and Myasthenia Gravis with Recurrent Thymoma
- 経皮酸素圧および皮膚灌流圧の測定による重症肢虚血の評価 (Evaluation of Critical Limb Ischemia by Transcutaneous Oxygen Pressure and Skin Perfusion Pressure Measurement)
- A Granulomatous Liver Abscess Which Developed After a Toothpick Penetrated the Gastrointestinal Tract : Report of a Case
- A Case of False Aneurysm of a Dacron Graft in Aortitis Syndrome
- Intralobar Pulmonary Sequestration Supplied by Multiple Anomalous Arteries : Report of a Case
- Mucosa-associated lymphoid tissue lymphoma in the thymus of a patient with systemic lupus erythematosus
- Evaluation of Critical Limbs Ischemia by Transcutaneous Oxygen Pressure and Skin Perfusion Pressure Measurement
- A Case of Bilateral Obturator Foramen Bypass
- Management of Isolated Iliac Artery Aneurysms : Iliac Artery Aneurysms not Associated with Abdominal Aortic Aneurysm
- CORONARY OSTIAL ENDARTERECTOMY IN TAKAYASU'S AORTITIS : Confirmation of Patency Nine Years Postsurgically
- MAXIMUM VENOUS OUTFLOW AND DEVELOPMENT OF DEEP VEIN THROMBOSIS
- -357- INTRAOPERATIVE EVALUATION OF BLOOD FLOW PROFILES IN CORONARY ARTERY BRIDGE BYPASS GRAFTS BY 20MHz80CHANNEL PULSED DOPPLERVELOCIMETER
- Surgical Treatment for Buerger's Disease Using the Left Radial Artery as a Graft Conduit
- Pulmonary Apical Mass, the So-Called Pulmonary Apical Cap, in a 43-Year-Old Woman
- Induction Chemoradiation Therapy with Cisplatin plus Irinotecan Followed by Surgical Resection for Superior Sulcus Tumor
- Triple-Chamber Cardiac Thrombosis in a Patient With Atrial Fibrillation and Severe Left Ventricular Dysfunction
- Total aortic arch replacement for a patient with poor left ventricular function and patent coronary artery bypass grafts : how to establish effective myocardial protection
- Long-term Results of Emergency Coronary Artery Bypass Grafting.
- Bypass vs. Endovascular Therapy of Infrapopliteal Lesions for Critical Limb Ischemia