Synthesis, oxygen activation, and DNA-cleaving property of a histidine-pyridine-histidine ligand

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概要

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• A novel metal-chelating system comprising a 4-dimethylamino-　pyridine and two histidine appendages was synthesized. The two histidines were introduced by different manners; one through an amide linkage and other via a secondary amino linkage. ESR spectrum suggested a distorted pentacoordinate configuration of the copper complex of the ligand. The iron complex of the ligand had oxygen-activating property as shown by ESR spin trapping and DNA-cleaving activity as evaluated by experiments using pUC19 DNA.

• The Japan Institute of Heterocyclic Chemistry,熊本大学の論文
• 2006-10-10

著者

• Okamoto Yoshinari

  Graduate School Of Medical And Pharmaceutical Sciences Kumamoto Univ.

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• Synthesis, oxygen activation, and DNA-cleaving property of a histidine-pyridine-histidine ligand

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