Functional evolution of Ets in echinoderms with focus on the evolution of echinoderm larval skeletons
スポンサーリンク
概要
- 論文の詳細を見る
Convergent evolution of echinoderm pluteus larva was examined from the standpoint of functional evolution of a transcription factor Ets1/2. In sea urchins, Ets1/2 plays a central role in the differentiation of larval skeletogenic mesenchyme cells. In addition, Ets1/2 is suggested to be involved in adult skeletogenesis. Conversely, in starfish, although no skeletogenic cells differentiate during larval development, Ets1/2 is also expressed in the larval mesoderm. Here, we confirmed that the starfish Ets1/2 is indispensable for the differentiation of the larval mesoderm. This result led us to assume that, in the common ancestors of echinoderms, Ets1/2 activates the transcription of distinct gene sets, one for the differentiation of the larval mesoderm and the other for the development of the adult skeleton. Thus, the acquisition of the larval skeleton involved target switching of Ets1/2. Specifically, in the sea urchin lineage, Ets1/2 activated a downstream target gene set for skeletogenesis during larval development in addition to a mesoderm target set. We examined whether this heterochronic activation of the skeletogenic target set was achieved by the molecular evolution of the Ets1/2 transcription factor itself. We tested whether starfish Ets1/2 induced skeletogenesis when injected into sea urchin eggs. We found that, in addition to ectopic induction of mesenchyme cells, starfish Ets1/2 can activate some parts of the skeletogenic pathway in these mesenchyme cells. Thus, we suggest that the nature of the transcription factor Ets1/2 did not change, but rather that some unidentified co-factor(s) for Ets1/2 may distinguish between targets for the larval mesoderm and for skeletogenesis. Identification of the co-factor(s) will be key to understanding the molecular evolution underlying the evolution of the pluteus larvae.
著者
-
Kiyomoto Masato
Marine And Costal Research Center
-
Kiyomoto Masato
Tateyama Marine Laboratory Ochanomizu University
関連論文
- Functional evolution of Ets in echinoderms with focus on the evolution of echinoderm larval skeletons
- ALKALINE PHOSPHATASE ACTIVITY IN THE ISOLATED ENDODERMAL TISSUE OF SEA URCHIN EMBRYO(Developmental Biology)(Proceedings of the Seventy-Third Annual Meeting of the Zoological Society of Japan)
- The culture conditions of sea urchin micromeres on the spicule formation and the effect of hypergravity
- Abnormal Gametogenesis, Male Dominant Sex Ratio, and Sertoli Cell Morphology in Induced Triploid Mussels, Mytilus galloprovincialis
- EFFECTS OF STEROID HORMONES ON THE DEVELOPMENT OF SEA URCHIN HEMICENTROTUS PULCHERRIMUS(Developmental Biology,Abstracts of papers presented at the 76^ Annual Meeting of the Zoological Society of Japan)
- Krüppel-like is required for nonskeletogenic mesoderm specification in the sea urchin embryo
- Two Types of Skeletogenic Cell in Sea Urchin Embryo(Multipotential Cells in Echinoderm: Evolution and Morphogenesis,Symposium,PROCEEDING OF THE 76^ ANNUAL MEETING OF THE ZOOLOGICAL SOCIETY OF JAPAN)
- AUTONOMOUS DIFFERENTIATION ABILITY OF THE ISOLATED ARCHENTERON IN THE SEA URCHIN EMBRYO(Developmental Biology,Abstracts of papers presented at the 75^ Annual Meeting of the Zoological Society of Japan)
- Marked Changes in the Ribonuclease Activity of Mature and Immature Gonads of Sea Urchins Hemicentrotus pulcherrimus and Anthocidaris crassispina(Biochemistry)
- Signals from primary mesenchyme cells regulate endoderm differentiation in the sea urchin embryo
- Skeletogenesis by transfated secondary mesenchyme cells is dependent on extracellular matrix-ectoderm interactions in Paracentrotus lividus sea urchin embryos
- THE SKELETOGENIC CELLS FORMING SPICULES OF THE LATE STAGE LARVAE AND THE ADULT RUDIMENT(Developmental Biology,Abstracts of papers presented at the 75^ Annual Meeting of the Zoological Society of Japan)
- Commitment and response to inductive signals of primary mesenchyme cells of the sea urchin embryo
- Par6 regulates skeletogenesis and gut differentiation in sea urchin larvae