The applications of time-frequency analyses to ictal magnetoencephalography in neocortical epilepsy
スポンサーリンク
概要
- 論文の詳細を見る
Purpose: Ictal magenetoencephalographic (MEG) discharges convey significant information about ictal onset and propagation, but there is no established method for analyzing ictal MEG. This study sought to clarify the usefulness of time-frequency analyses using short-time Fourier transform (STFT) for ictal onset and propagation of ictal MEG activity in patients with neocortical epilepsy. Methods: Four ictal MEG discharges in two patients with perirolandic epilepsy and one with frontal lobe epilepsy (FLE) were evaluated by time-frequency analyses using STFT. Prominent oscillation bands were collected manually and the magnitudes of those specific bands were superimposed on individual 3D-magnetic resonance images. Results: STFT showed specific rhythmic activities from alpha to beta bands at the magnetological onset in all four ictal MEG records. Those activities were located at the vicinity of interictal spike sources, as estimated by the single dipole method (SDM), and two of the four ictal rhythmic activities promptly propagated to ipsilateral or bilateral cerebral cortices. The patients with FLE and perirolandic epilepsy underwent frontal lobectomy and resection of primary motor area, respectively including the origin of high-magnitude areas of a specific band indicated by STFT, and have been seizure free after the surgery. Conclusions: STFT for ictal MEG discharges readily demonstrated the ictal onset and propagation. These data were important for decisions on surgical procedure and extent of resection. Ictal MEG analyses using STFT could provide a powerful tool for noninvasive evaluation of ictal onset zone.
著者
-
Saitoh Shinji
Department Of Pediatrics Hokkaido University Graduate School Of Medicine
-
Asahina Naoko
Department Of Pediatrics Hokkaido University Graduate School Of Medicine
-
Saitoh Shinji
Department Of Pediatrics Graduate School Of Medicine Hokkaido University
-
Shiraishi Hideaki
Department Of Pediatrics Hokkaido University Graduate School Of Medicine
-
Sueda Keitaro
Department Of Pediatrics Hokkaido University Graduate School Of Medicine
-
Saitoh Shinji
Department of Pediatrics, Hokkaido University Graduate School of Medicine
関連論文
- The applications of time-frequency analyses to ictal magnetoencephalography in neocortical epilepsy
- Generalized spike-wave discharges involve a default mode network in patients with juvenile absence epilepsy : A MEG study
- MEG time-frequency analyses for pre- and post-surgical evaluation of patients with epileptic rhythmic fast activity
- Possible involvement of the tip of temporal lobe in Landau-Kleffner syndrome
- An infantile/juvenile form of Alexander disease caused by a R79H mutation in GFAP
- Application of Magnetoencephalography in Epilepsy Patients with Widespread Spike or Slow-wave Activity
- Uniparental disomy and imprinting defects in Japanese patients with Angelman syndrome
- A novel splicing mutation of the ATRX gene in ATR-X syndrome
- A novel P gene missense mutation in a Japanese patient with oculocutaneous albinism type II (OCA2)
- Non-chromosome 15 marker chromosome in a Prader-Willi syndrome patient with uniparental disomy
- Prader-Willi syndrome in a child with XYY
- Vaccine-associated paralytic poliomyelitis in a non-immunocompromised infant
- Source localization in magnetoencephalography to identify epileptogenic foci
- Clinical application of array-based comparative genomic hybridization by two-stage screening for 536 patients with mental retardation and multiple congenital anomalies
- Copy-number variations on the X chromosome in Japanese patients with mental retardation detected by array-based comparative genomic hybridization analysis