CNVの記録条件と非定型波形の生理学的意義
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CNVの記録条件を検討する目的で、健康若年成人49名（男12、女37）を対象にS(1)-S(2)+Rパラダイムを用いてCNVを記録した。S(1)-S(2)間隔2秒のほうが3秒よりも安定してCNVが記録されたが、刺激間隔とは無関係に26～30％の試行で二峰性の陰性変動をもつ非定型な緩電位が記録された。この緩電位は同一被検者でも出現性が一貫せず、個体差よりも被検者の状態に依存していた。二峰性陰性波のうち、後期成分は準備電位に対応するものと思われたが、前期成分はS(1)後900～1100msecにピークをもつ陰性波で、これまで報告されたCNVの要素波とは対応しなかった。また、この非定型CNVを示す被検者ではCNV出現が不安定で、SVRおよびパターンVEPの振幅が低い傾向があり、試行時の被検者の覚醒水準低下よるものではないかと考えられた。We recorded a slow negative potential from Cz (10/20 method) in 49 healthy students (12 male, 37 female, mean age 19.1) by a short interstumulus interval CNV paradigm. The interstimulus interval was 2 or 3 seconds, the warning stimulus presented at random or regular interval at 0.2 Hz. An atypical negative variation with two separated negative peaks was recorded in 26.0-30.6% trials regardless of interstimulus interval or modality of warning stimulus presentation, while a typical CNV was recorded in 32.0-59.2% of trials. No apparent negative variation was recorded in 14.3-18.4% in 2 seconds interstimulus interval, and 28-38% in 3 seconds interstimulus interval, showing that 2 seconds interval is better to get stable CNV recording than 3 seconds interval. The first negative wave of the atypical negative variation was 692-799msec in duration, but frequently prolonged to 1000msec or more in 3 seconds interval. It usually had negative peak around 900-1100msec, but sometimes around 1500msec. This features are different from any reported negative components of CNV. The second negative wave began 800-1200msec before second stimulus, and had its peak just before second stimulus, showing common features with readiness potential. The appearance of CNV was unsatble in the students in which the atypical negative variation was recorded in regular, 2 seconds intersitimulus interval, and the amplitude of slow vertex response and pattern reversal visual evoked potential was lower in thses students than in the students in which a typical CNV was recorded more than 3 times in total 4 times of trials. These findings indicate that the atypical variation observed in this study is due to a lowered arousal level or cortical neuronal activity, rather than a separated appearance of different components of CNV.
- 岡山大学医療技術短期大学部の論文
- 1991-03-25
岡山大学医療技術短期大学部 | 論文
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