骨髄異形成症候群における Sideroblastogram の臨床的意義に関する検討

スポンサーリンク

概要

• 論文の詳細を見る

• Clinical utility of sideroblastogram was evaluated by analyzing the sideroblastogram and other clinical data in 66 patients with myelodysplastic syndrome (MDS) [nine with refractory anemia (RA), 27 with RA with excess blasts (RAEB), 24 with RAEB in transformation (RAEBt), and six with chronic myelomonocytic leukemia (CMMoL)]. The sideroblastogram was constituted based on the classification of erythroblasts according to the numbers of stainable iron granules in their cytoplasm : briefly, type 0 as no granules, type Ⅰas 1～2 granules, type Ⅱas 3～5 granules, type Ⅲ as more than 6 granules.The type Ⅲ dominant sideroblastogram (type Ⅲ predominace) was observed in 73% of the patients with MDS in contrast with type 0～Ⅰ predominance in 100% of the healthy volunteers. Although type Ⅲ predominance appeared distinctly in patients who presented erythroid morphological abnormalities, 50% of the patients without abnormalities also had type Ⅲ predominance. Patients with type Ⅲ predominance had more severe macrocytic anemia compared with other dominant types, but type Ⅲ predominance did not influence the disease prognosis. In two cases the sideroblastogram was normalized at complete remission, and returned to type Ⅲ dominance at recurrence of the disease. The type Ⅲ dominant sideroblastogram reflects the disorders of iron metabolism in erythroblasts, and the normalization of the sideroblastogram indicates the appearance of normal etythropoiesis from the normal clone in marrow. We conclude that the sideroblastogram is useful not only in diagnosing MDS but also in clinical evaluation of the therapeutic effect.

• 岡山医学会の論文
• 1994-08-00

著者

• 小島 研介

  岡山大学医学部第二内科

関連論文

• 急性血小板減少が先行した成人水痘
• 骨髄移植後に発症したBronchiolitis obliterans と思われる呼吸器障害の診断に吸気呼気CTが有用であった1例
• 多発性の肺内転移巣に薄壁空洞を生じた中分化型肺腺癌の1例
• 骨髄異形成症候群における Sideroblastogram の臨床的意義に関する検討

スポンサーリンク