Correlation between pulmonary function and low attenuation area (LAA) on HRCT III patients with asthma in relation to smoking
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概要
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気管支喘息49例を対象に､肺機能およびHigh resolution computed tomography(HRCT)上のLow attenuation are (LAA) <-950HUで示される肺気腫様変化に及ぼす喫煙の影響について検討した｡ 1.気管支喘息患者のうち､非喫煙例では% 残気量(% RV)は多くの症例(65.6% )で129% 以下であったが､一方喫煙症例では130% から189% を示す症例が最も多く見られた(60.0% )｡非喫煙例および喫煙例いずれにおいても､2.% RVと% LAA､% RVとCT number 間に有意の相関が見られた: % RVが上昇するにつれて､% LAA値は増加し､CT numberは低下する傾向が見られた｡ 3.喫煙例では､% RVが130-189% あるいは190% 以上の症例で､% DLco値が明かに低値を示す症例が見られたが､非喫煙症例では% RVが高い値を示しても% DLcoの低下はみられなかった｡ 4.喫煙例､非喫煙例いずれにおいても､% FEV1.0倍と% RV値の問には有意の相関が見られ､% RV値が上昇するにつれて､% FEV1.0値は低下する傾向が見られた｡ 5.% FVCと% RVの問には相関は見られなかった｡以上の結果より､喫煙は気管支喘息患者のHRCT上の% LAAおよび% DLcoに影響を与えることが示唆された｡The influence of smoking on pulmonary function and emphysematous changes of the lung (percentage of attenuation area < -950 HU (% LAA) on high resolution computed tomography (HRCT) was examined in 49 patients with bronchial asthma. 1. In patients with asthma, the % residual volume (RV) in many nonsmokers was less than 129%, in contrast, the % RV in many smokers was between 130% and 189% , which was higher than that in nonsmokers. 2. Significant correlations between % RV and 96LAA value, and between % RV and CT number were observed both innonsmokers and smokers with asthma, in which as % RV more increased, % LAA value was larger, and CT number was lower. 3. % DLco value was lower in smoking patients with asthma, whose % RV was between 130% and 189% and larger than 190% , however, the % DLco value did not change in nonsmoking patients despite of higher valure in % RV. 4. A significant correlation was also observed between % FEV1.0 value and % RV both in smoking and nonsmoking patients with asthma; as % RV value more increased, % FEV1.0 value was lower. 5. Any correlation between % FVC value and % RV was not observed. These results suggest that smoking affects the % LAA of the lung on HRCT and % DLco in patients with asthma.
- 岡山大学医学部附属病院三朝分院の論文
- 2001-02-01
岡山大学医学部附属病院三朝分院 | 論文
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