An Efficient, One-Pot Synthesis of Fosfomycin Dialkyl Esters from (R)-2-Tosyloxypropanal
スポンサーリンク
概要
- 論文の詳細を見る
(R)-2-Tosyloxypropanal (4) was prepared from D-mannitol in a 7-step sequence (51% overall yield). Addition of dialkyl phosphonates to 4 in the presence of titanium isopropoxide and the subsequent treatment with DBU stereoselectively afforded, in one-pot, fosfomycin dimethyl (5a) and dibenzyl (5b) esters both in 58% isolated yield.
- The Japan Institute of Heterocyclic Chemistryの論文
著者
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Hanaya T
Okayama Univ. Okayama Jpn
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Hanaya Tadashi
Okayama Univ. Okayama Jpn
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Yamamoto Hiroshi
Shujitsu Univ. Okayama Jpn
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