神経因性膀胱の薬物療法 --利尿筋-尿道外括約筋dyssynergia症例へのTolperisone hydrochlorideの投与の試み--

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概要

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• There are many patients with neurogenic bladder who complain of dyssynergia between detrusor and external urethral sphincter. Intra-abdominal pressure. vesical pressure, urethral pressure, tonus and electromyogram of sphincter ani and urine flow rate were determined and recorded simultaneously with a polygraph with six channels. Dyssynergia between detrusor and external urethral sphincter could be clearly confirmed by this method. Tolperisone hydrochloride, a striated muscle relaxant, was administered to the pcltients with neurogenic bladder demonstrating dyssynergia. Urodynamic examinalions were carried out before and after drug administration. In regard to the major symptoms of neurogenic bladder, dysuria and incontinence, it was found that the drug was effective for the former but ineffective for the latter. It was therefore assumed that the combined use of smooth muscle contracting agents with Tolperisone hydrochloride would enhance its effect. The pattern of dyssynergia between detrusor and external urethral sphincter did not return to normal even with administration of Tolperisone hydrochloride.

• 泌尿器科紀要刊行会の論文

著者

• 福井 準之助

  信州大医

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• 潜在性二分脊椎を有し,脊髄下部の牽引により生じた先天性神経因性膀胱(いわゆるTethered Cord Syndrome)の尿水力学的,電気生理学的検査法による術前および牽引除去後の評価
• 神経因性膀胱の薬物療法 --利尿筋-尿道外括約筋dyssynergia症例へのTolperisone hydrochlorideの投与の試み--

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