慢性腎不全の長期血液透析療法におけるAnabolic steroidsの効果について

概要

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One of the anabolic steroid hormones, Primobolan Depot, was administered to the patients who were on the maintenance hemodialysis due to chronic renal insufficiency. The dosage was 200 mg or 400 mg per week. The following results were obtained. 1. Blood transfusion required to maintain our standard (RBC 2×10[6], Hb45 %, Ht18-20 %) was less than in the control group. These hematological parameters changed much less and became rather stable in the administered group. 2. Slight elevation of the serum protein and A/G ratio were observed in the administered group. 3. The steroid did not give influence on the serum level of electrolytes, urea nitrogen and creatinine. 4. Bone marrow study always showed suppression of the function in these patients. The anabolic steroid hormone was proved to improve erythropoiesis. 5. It was concluded that administration of anabolic steroid hormone associated with food protein of 1 g per kg body weight would give a good result to the patients. 6. As to side reactions, amenorrhea, acne vulgaris and hirsutism were seen in a few cases, but no liver damage was proved in any case.
泌尿器科紀要刊行会の論文