膀胱腫瘍の酵素学的研究-2-膀胱癌組織におけるLactic Dehydrogenase,Alkaline Phosphatase活性ならびにLDH Isoenzymesと浸潤度および組織学的悪性度との相互関係について

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Forty-four bladder specimens surgically removed, 28 obvious cancer and 16 tissues free of cancer as control, were submitted to quantitative study of LDH, LDH isoenzymes and alkaline phosphatase; and they were investigated as to stage (Jewett) and grade (Broders). The following results were obtained. 1) The bladder cancer tissues showed high LDH activity, which increased with advance of stage but was low contrally in the undifferentiated carcinomas. 2) High percentage of LDH-V was proved in the cancer tissues as compared with the control, but there was no correlation with stage and grade. LDH-IV showed a similar tendency with LDH-V, and its ratio was higher in the undifferentiated carcinomas than in the differentiated. LDH-III showed lower percentage in the cancer tissues than in the control, and there was no correlation with stage and grade. LDH-II showed no difference as to presence of cancer or stage and grade. LDH-I in the cancer tissues was lower than in the control and decreased with advance of histological malignancy. 3) Alkaline phosphatase showed no difference between cancer and the control or among the various stages and grades.
泌尿器科紀要刊行会の論文