精索静脈瘤に対するParaphlebonの効果

概要

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It is now well known that varicocele often causes male infertility and its operative treatment is indicated. However, drug therapy of varicocele has not been investigated. Paraphlebon, an effective drug on varicose vein, was clinically tried for treatment of male infertility due to varicocele. Through this study, mechanism of ill effect of varicocele on spermatogenesis was investigated. Paraphlebon was orally administered to eighty-five patients 'with varicocele for three weeks to three months. The following results were obtained. 1. Varicocele disappeared or remarkably regressed in twenty-nine patients. The rest of the patients showed some regression. 2. Sperm count increased in 70 of 79 patients. 3. Sperm motility increased in 72 of 79 patients. 4. Testicular histology before the treatment was normal in 21 of 43 biopsies. But it was normal in 30 after the treatment. 5. Out of 34 infertile males, 9 had pregnancy within one year after the treatment. The clinical results of Paraphlebon, seem to be as good as operative treatment. It was not elucidated why the unilateral varicocele affects spermatogenesis of the other side. Since spermatogenesis has improved by the drug therapy, long-standing ischemia of the testis seems to exert hypospermatogenesis of the contralateral testis. This hypofunction may be reversible to some extent.
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