[原著］拡大肝切除時に網内系賦括剤の投与や脾摘の意義に関する実験的研究
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概要
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The purpose of this study is to evaluate the influence of increased activity of reticuloendothelial function by OK-432 and splenectomy on hepatic regeneration following 93% hepatectomy in rats. Wister-maie rats weighting 240g to 320g were randomly allocated to 4 experimental groups and subjected to the following regimen :(1) A group; 93% hepatectomy alone,(2) B group; 93% hepatectomy+splenectomy, (3) C group; OK-432+93% hepatectomy, (4) D group; OK-432+93% hepatectomy+splenectomy. Survival rates after hepatectomy, initial, 24hour, 48hour, serum endotoxin, S- GOT, S-GPT in each group were determined. The long-term (180 days following hepatectomy) survival rates was 45.5% in A group, 13.6% in B group, 6.4% in Cgroup and 6.3% in D group, respectively and A group survival was statistically significant better compared with other three groups. Serum endotoxin titers prior to hepatectomy were significantly lower (0.926 pg/ml) in OK-432 treated groups than in non-treated groups (3.3pg/ml). 24hours after hepatectomy, A group showed marked increase titers of endotoxin with statistical significance compared with other three groups. S-GOT and S-GPT markedly elevated 24hours after hepatectomy, but returned to the normal values 48hours after hepatectomy. These results might suggest that in 93% experimental hepatectomy in rats, activation of reticuloendotherial function could be harmful in liver regeneration after hepatectomy, and lower survival rate from the long-term survival points, therefore, another unknown mechanism might play an important role in liver damage after hepatectomy.
- 琉球医学会,Ryukyu Medical Associationの論文