テロジリンの下部尿路機能に対する作用

概要

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除脳犬を対象として,pressure flow EMG法を用いてテロジリンのウロダイナミックパラメーターに及ぼす効果について検討した.膀胱に対する抑制作用が明らかに認められ,過活動性膀胱症例に対する有用性が期待されたThe effects of terodiline on lower urinary tract function were studied using decerebrated dogs. The micturition cycles were investigated by pressure flow EMG study before and after the administration of terodiline. The statistical analysis was carried out on the urodynamic parameter. Terodiline at a dose of 1 mg/kg decreased the opening pressure, contraction pressure, and flow rate and increased the residual volume. A decrease in threshold pressure, average flow rate and an increase in bladder compliance also occurred after the administration of terodiline at the dose of 3 mg/kg. Terodiline appears to decrease bladder activity and is useful for pollakisuria.