男性不妊症に対するカリクレインの臨床評価

概要

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44名の特発性男性不妊症患者にたいして,カリクレイン1日90～120 KUを3ヵ月間経口投与したところ,精子濃度,精子運動率および妊孕係数に対する有効率はそれぞれ,51.1%,37.2%,32.9%であった.薬剤投与により精子濃度および妊孕係数には有意の改善が見られたが,精子運動率,精液量および精子奇形率に対しては治療前後で有意の改善は認められなかった.44名中4名が妊娠に成功したKallikrein was orally administered to 44 patients with male infertility at a dose of 90 or 120 KU/day for three months. The sperm density, sperm motility and fertility index (F.I.) were improved in 51.1%, 37.2% and 38.9% of the treated patients, respectively. Statistical analysis showed that significant improvement was noted in sperm density and F.I. between before and after the treatment, but not in sperm motility, sperm volume nor sperm morphology. During the period of treatment, in these treated 44 patients, 4 patients (9.1%) succeeded in pregnancy.