蓄尿作用を有するinaperisoneの橋における作用部位の同定

概要

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inaperisoneを,除脳ネコの橋排尿中枢である青斑核アルファ(LCa),橋蓄尿中枢である青斑下核(LSC)と膀胱収縮抑制作用のある吻側橋網様核背部(PoO)に局注した.1) LCaとPoOへの注入では,反射性排尿に変化がみられなかった.2) LSCへの注入では膀胱容量の増加,排尿量の減少と残尿量の増加がいずれも有意であったが,最大膀胱収縮圧には影響しなかったTo identify the effective region of the pons in response to inaperisone which facilitates urine storage, inaperisone (100 mM, 0.2 microliters) was injected into the nucleus locus coeruleus alpha (LCa, the pontine micturition center), the nucleus locus subcoeruleus (LSC, the pontine urine storage center) and the nucleus reticularis pontis oralis (PoO, micturition inhibitory region) of the decerebrate cats. On reflex micturition, inaperisone injection into the LSC decreased voiding volume, and increased residual volume and bladder capacity, significantly. However, there was no difference in the maximum bladder pressure before and after inaperisone injection into the LSC. Inaperisone injection into the LCa or the PoO had no influence on reflex micturition. These results suggest that effective region of the pons in response to inaperisone is the LSC, and that inaperisone facilitates the urine storage neural mechanism in the LSC.