印環細胞癌を伴った膀胱移行上皮癌の1例

概要

論文の詳細を見る
58歳男で,肉眼的血尿,頻尿を主訴とし,膀胱鏡検査で前壁,頂部,左側壁,膀胱頸部に示指頭大迄の広基性乳頭状腫瘍が認められた.膀胱腫瘍の診断のもと経尿道的切除術を行い,病理診断が膀胱原発印環細胞癌であったことから更に膀胱尿道全摘術を施行した.病理標本の検討から印環細胞癌は移行上皮癌の分化・腺様化成に由来することが推測されたA 58-year-old man visited our clinic with complaints of gross hematuria and pollakisuria. Cystoscopic examination revealed multiple non-papillary broad based tumors and reddish unstable mucosa in the bladder. The pathological specimen of the transurethral biopsy of the tumors showed signet-ring cell carcinoma predominantly and adenocarcinoma transforming into signet-ring cell carcinoma partially. A total cystectomy with ileal conduit urinary diversion was performed. The histopathological finding of the radical cystectomy specimen was grade 3 transitional cell carcinoma accompanied by adenocarcinoma. These findings suggest that the adenomatous metaplasia of transitional cell carcinoma in the bladder could differentiate into signet-ring cell carcinoma.