長期経過観察しえた尿膜管癌5例の臨床的検討
スポンサーリンク
概要
- 論文の詳細を見る
1)Sheldonらの分類でstage IIIA迄の尿膜管癌の初回手術として,臍・尿膜管全摘除術を加えた膀胱部分切除術にて長期の生存,膀胱温存が得られる可能性が示唆された.2)CEAは患者血清4例中2例,尿膜管癌組織5例中5例で陽性であり,尿膜管癌の腫瘍マーカーとなる可能性が示唆された.3)p53は尿膜管癌組織5例中4例で陽性であったが,stageや予後との相関は認められなかったFive cases of urachal carcinoma experienced in our hospital during the past 20 years are reported. Surgical resection is considered as the first treatment option of this disease, and other therapies to be less beneficial. Complete surgical extirpation and detection of recurrence in the early stage are considered to be important since local recurrence occurs frequently. We enforced the bladder preserving operation for 4 patients with urachal carcinoma except for 1 case with peritonitis carcinomatosa in the initial diagnosis, and multiple surgical treatment was performed again for 2 patients with recurrence. The bladder was preserved with no evidence of malignancy in three patients for 24, 19 and 5 years, respectively. In the initial management of urachal carcinoma, we believe that bladder-preserving surgery should be considered in selected cases though close follow-up is demanded. Herein, we also report the immunohistochemical study of paraffin-embedded specimens using anti-CEA, CA19-9, CA125 and p53 monoclonal antibodies. The positive reaction was observed in 100% (5/5) for CEA, 80% (4/5) for CA19-9, and 20% (1/5) for CA125. These results suggest that CEA may be a useful marker in the diagnosis of this neoplasm and early detection of its recurrence. Nuclear accumulation of p53 was observed in 80% (4/5), but it did not correlate with the disease progression.
著者
関連論文
- PP-078 新規軟部肉腫転移関連遺伝子C7059の前立腺癌における機能解析(前立腺/基礎2,一般演題ポスター,第97回日本泌尿器科学会総会)
- 腎盂尿管癌の臨床的検討
- PP2-027 Kock pouchおよびileal neobladderにおけるハンモック尿管回腸吻合術の長期成績(一般演題(ポスター))
- PP-212 cDNA microarrayを用いた尿路上皮癌化学療法感受性予測因子同定の試み(尿路上皮腫瘍/基礎,一般演題ポスター,第96回日本泌尿器科学会総会)
- APP-027 尿路移行上皮癌におけるtriptolideを用いた癌特異的p21 target therapy(尿路上皮腫瘍・精巣腫瘍/基礎,総会賞応募ポスター,第96回日本泌尿器科学会総会)
- 腎炎症性偽腫瘍の1例
- 直腸診触知不能のPSA上昇例及びStage A前立腺癌におけるPSA, PSA densityの検討
- 同側腎無形成を伴った精嚢嚢胞の1例
- 長期経過観察しえた尿膜管癌5例の臨床的検討
- 局所浸潤性膀胱癌に対するCOMPA動注化学療法の検討。
- 根治的前立腺全摘術施行例における術前術後の病理組織学的検討
- Urinary"Urge Syndrome"に対するIPD^の臨床効果 : 尿中Interleukin-6(IL-6)濃度と末梢血免疫担当細胞からみた免疫学的検討
- 巨大な腸腰筋膿瘍の1例
- 膀胱Nephrogenic adenomaの3例
- 腎盂尿管癌の臨床的検討
- OP-114 膜温存体腔鏡下前立腺全摘除術におけるpositive surgical marginの検討(体腔鏡/前立腺,一般演題口演,第99回日本泌尿器科学会総会)
- APP-046 術前のretrograde leak point pressureは腹腔鏡下前立腺全摘除術後の尿禁制予測の指標となりうる(総会賞応募ポスター,第99回日本泌尿器科学会総会)
- OP-100 Homemade single-port deviceを用いた肝挙上用追加ポートを必要としないlaparoendoscopic single-site right adrenalectomyの経験(体腔鏡/副腎・腎・尿管・腹部,一般演題口演,第99回日本泌尿器科学会総会)