Studies of Immunoglobulins in Gastric Juice and Gastric Mucosa. IV. Studies on Secretory Component in Gastric Mucosa
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概要
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The changes of secretory component (referred to as SC) in the gastric mucosa of various gastric diseases were investigated by immunofluorescent technics. In the foveolar cells of normal gastric mucosa characteristic granular fluorescence of free SC (referred to as FSC) was observed intensely. However, the fluorescence of FSC showed various patterns corresponding to the mucosal changes with intestinal metaplasia; i. e., specific granular fluorescence of FSC was observed in goblet cells in low grade intestinal metaplasia but not observed in goblet cells in the mucosa of advanced stages of intestinal metaplasia. The specific granular fluorescence of FSC which is seen in normal conditions, decreased in the absorptive cells with advanced stage of intestinal metaplasia. The diminished fluorescence of FSC in the advanced stage of intestinal metaplasia are considered to suggest the depressive function of the secretory immune system. The detection patterns of FSC in gastric carcinoma were also found in various manners according to the histological types; i. e., generally no cytoplasmic except for a very weak fluorescence in the well differentiated types, and very strong but not granular fluorescence of FSC was observed, in contrast, in the case of signet ring cell carcinoma. FSC detection in the carcinoma tissue showing aberrent patterns was considered to he interesting in the elucidation of dedifferentiation of the tumor cells associated with the secretory immune system.
- 札幌医科大学の論文
- 1977-12-01
札幌医科大学 | 論文
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