細胞性免疫に関する臨床的研究 第III編 担癌患者における細胞性免疫能の変化および癌特異免疫検出の試み
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Studies on cell-mediated immune responses in 102 patients with various cancers were carried out, and simultaneously, an attempt to detect the specific immunity against 3 M KCI soluble antigen of cancer cells was undertaken using the leukocyte migration inhibition test in a part of the patients. The results obtained were as follows : 1) Cancer patients showed reduction in delayed skin reactions to both PPD and Candida antigens, in stimulation index (SI) of lymphocyte blastogenesis to PHA, in total lymphocyte numbers per mm3, as well as in T and B lymphocyte count. However, there less reductions in PPD skin reaction and lymphocyte count in lung cancer as compared with those in other cancers. No significant difference in T and B lymphocyte proportion and SI was seen among various cancers. 2) Although the correlation between T lymphocyte count and SI was noted in healthy controls, it was not significant in cancer patients. This result suggested that T lymphocyte per se may be impaired in its function in cancer patients. 3) Remarkable reductions in cell-mediated immune responses were found in parallel with the advancement in the stage of cancers. 4) The immune reactivities were compared between groups with and without chemotherapy or immunochemotherapy, especially in gastric cancer of IVth stage, and a tendency of recovery of the changes to normal was noted in the group undergoing immunochemotherapy. 5) Specific immune reactivities to autochthonous and allogeneic cancer cell antigens, which were prepared by 3 M KCI extraction as antigens from cancer cells in ascites and from gastric cancer tissues, were investigated using leukocyte migration inhibition (LMI) test. On the 7 antigens extracted from ascites tumor cells, 1 out of 7 cancer patients showed weakly positive on LMI against autochthonous antigens, and 1 positive and 4 weakly positive reactions on LMI test were detected in 19 patients against allogeneic antigens. On the 3 antigens extracted from gastic cancer tissues, 1 out of 2 cases of the autochthonous system showed positive reaction, and 2 of each weakly and clearly positive reactions were seen in 9 cases of allogeneic test system. It was suggested from the results that cancer-specific immune responses might be detected even in the advanced stages of cancer by use of LMI test, and discussions are made in connection with HL-A in the test system.
- 札幌医科大学の論文
- 1976-06-30
札幌医科大学 | 論文
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