珪肺症の臨床病理学的研究 II. 珪肺症と肺癌の合併についての統計的検討
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Cancer of the lung was found in 37 cases out of 229 autopsies of silicosis at the Iwamizawa Rosai Hospital (Hospital for Workers' Accidental Diseases) during 1956-1973. A statistical study was carried out on the relationship between silicosis and cancer of the lung. Because almost all silicotic patients in Hokkaido have visited the Iwamizawa Rosai Hospital and all victims of silicosis have been autopsied in this hospital, sampling error may be considered to be negligeble. Results of the statistical analysis were as follows : 1. The incidence of lung cancer in silicotic patients is significantly high compared with that in the entire autopsies of the same age level males performed in Japan, and also compared with the death rate of lung cancer of Japanese males of the same age level during 1966-1968. 2. Deviation of age distribution of lung cancer associated with silicosis was not significant. 3. Correlation of lung cancer to smoking and tuberculosis in patients of silicosis was not seen. 4. Association of lung cancer with silicosis was more frequent in coal miners than in metal miners. 5. Average latent period of lung cancer associated with silicosis was estimated to be 24 years or over. 6. Coincidence of lung cancer and silicosis was estimated fallaciously low in the past. Wide variations among many statistical reports on the coincidence of silicosis and lung cancer might be attributed to the time in which the studies were done, to statistical methods employed, to geographical factors, and particularly to the participation of mortality rate of other causes of deaths. These results strongly suggest an etiological correlation of silicosis to lung cancer.
- 札幌医科大学の論文
- 1975-08-30
札幌医科大学 | 論文
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