Coenzyme Q10 の心筋保護効果についての形態学的検討　―とくに左室肥大心を用いて―

概要

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Many investigations have been carried out on the protection of myocardium from ischemic injury during open heart surgery. This experiment was designed to study the protective effects of Coenzyme Q10 (CoQ10) on the ischemic myocardium using the dogs with left ventricular hypertrophy. Ischemia was induced by aortic cross clamp under mild hypothermia for 2 hours. Thereafter the heart was reperfused for 30 min. by a release of the clamp. In the control group, which was not treated with CoQ10, many intramitochondrial amorphous densities, which had been reported as beeing an early marker of irreversible changes in myocardial cells, were observed at 2 hours after the aortic cross clamp. On the other hand, in the experimental group which was given CoQ10 prior to and during the aortic cross clamp, there were only few intramitochondrial amorphous densities. The changes in the control group deteliorated within 30 min. after reper fusion, but not so severely in the CoQ10 treated group. These results morphologically demonstrate the protective effects of CoQ10 on the myocaridum from ischemic injury.
札幌医科大学の論文
1981-12-01