Calicivirusによる乳幼児胃腸炎の研究

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In October 1977 and August 1979, two outbreaks of acute-gastroenteritis occurred in an infant home in the city of Sapporo, Japan. During the outbreaks, out of 93 residents of one to 27 months old, 77 (83%) showed some intestinal symptoms, inculding diarrhea in 73 (95%), vomiting in 34 (44%) and fever in 14 (18%). Electron microscopic examinations revealed typical calicivirus particles in fecal specimens derived from the two outbreaks. During these outbreaks 61 stool specimens were examined, and 29 (48%) were found to contain calicivirus particles. Relationship between fecal shedding of the virus and the days of illness was clearly demonstrated. Immune electron microscopic (IEM) tests for antibody responses against one of the isolated strains of calicivirus were carried out on 27 paired pre-illness and convalescent sera derived from the former outbreak. Serocoversion was demonstrated in 18 (95%) of 19 affected infants and in six (75%) of eight unaffected infants. Based on the results of IEM tests, the calicivirus appeared to have no antigenic relationship to five candidate viruses for gastroenteritis so far reported : Norwalk agent, Hawaii agent, W agent, Otofuke agent and the small round virus-like particles. Serum specimens from children and adults living in Sapporo were tested for antibody against calicivirus by IEM, using the virus-rich fecal extracts as the source of antigen. Of 83 serum specimens tested, 49 (59%) were positive for anti-xalicivirus antibody. The age-related prevalence of antibody to calicivirus suggested that calicivirus infection begins in later infancy and is accelerated in nursery, kindergarten or pirmary school. The findings provide us with evidence for the etiologic role of human calicivirus in infantile gastroenteritis.
札幌医科大学の論文
1981-06-01

Calicivirusによる乳幼児胃腸炎の研究

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概要

札幌医科大学 | 論文

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