Mechanical Responses of Rabbit Superior Rectus Muscle. Acetyleholine Contracture of Depolarized Muscle by Potassium

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The effect of extracellular K ions on ACh contracture of rabbit superior rectus muscle was studied, and the following results were obtained. 1) A transient response was elicited by 120.8 mM K, and transient and sustained responses were induced by 10-4 g/m? ACh. 2) K-contractures in the Ringer solution containig concentrations ranging from 43.4 to 101.4 mM K ions consisted of transient and sustained tensions. The extent of the sustained tension decreased with increasing of concentration of K. 3) Contracture was elicited by ACh in 43.4-101.4 mM K Ringer solution. The extent of the contracture decreased with increasing of concentration of K, and the contracture nearly disappeared at 101.4 mM K. 4) The contracture was again produced by ACh on higher K-concentrations (above 120.8 mM) and was slow and sustained. The contracture failed in the absence of calcium and was markedly inhibited by d-tubocurarine. 5) The second phase of control ACh contracture disappeared in Ca-defficient medium and the control ACh contracture was completely inhibited by d-tubocurarine.
札幌医科大学の論文
1980-02-01