抵抗血管の生体内昇圧物質に対する反応性に関する研究
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概要
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In the present study, we investigated the effects of extracellular sodium concentration (Na) o, osmolality and prostaglandin Ei(PGEi) on basal vascular tone and the response to the pressor agents, noradrenaline (NA) or angiotensin II (AT-II) using the pref used central artery of the isolated rabbit ear. The following results were obtained. 1) Both the basal vascular tone and the vasoconstrictor response of resistance vessels to NA were enhanced with a decreased extracellular osmolality induced by alteration in both sucrose concentration and(Na)o. 2) While the response to NA was not affected by (Na)o under constant osmolality, the response to AT-II was augmented significantly when (Na) o was increased from 102 mM to 132 mM. 3) The inhibitory action of PGE1 on the response to NA was influenced by alteration of the extracellular calcium concentration (Ca)o, and was greater when (Ca)o was less than 2.0 mM. 4) When 0.1μg and 1.0μg of NA were applied repeatedly and alternately, the responses were gradually enhanced. However, their enhancement was reduced under perfusion of PGE1(10ng/ml), the responses finally being inhibited. From the results described above, it was concluded that the response of the resistance vessels to NA was affected by alteration not in external Na concentration, but in external osmolality and calcium concentration. Further, it may be considered that the inhibitory effect of PGE1 on the response to NA is probably due to each antagonistic action on calcium ion mobility through the cell membrane or within smooth muscle cells at contraction due to NA.
- 札幌医科大学の論文
- 1979-10-01
札幌医科大学 | 論文
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