最近の年齢別ポリオ中和抗体保有状況

概要

論文の詳細を見る
In order to assess the present status of immunity against poliovirus of the general populationarising from mass vaccination with live oral Sabin vaccine carried out since 1961, sera obtained from residents in Sapporo and its outskirts were examined for virus-neutralizing antibodies against poliovirus types 1 and 3 with microtransfer technique using LLCMK2 cells. Examination of the data obtained from those under 15 years of age revealed that the duration ofimmunity conferred by live oral poliovaccine varied according to the type of virus: at 10-14 years of age, the percentages of those having neutralizing titers ?l: 4 were 82% for type 1 and 60% for type 3,and the rates of those with titers ?l: 64 were 12% for type 1 and 9% for type 3, respectively. An early disappearance of type 3 antibody due to poor immunogenicity of the vaccine was noted. Those of 18 years of age or older who might have been exposed to natural infection of poliomyelitis in their infancy possessed higher antibody titers against both types, as compared to those under 15 years of age. These titers, however, were still significantly lower than the titers in serum obtained from inhabitants living in an endemic country (Timor Island, Indonesia). Based on these results, the importance of a careful follow-up of herd immunity in the futureespecially among those who had acquired immunity by vaccination alone was emphasized.
札幌医科大学の論文
1979-02-01