ジアゼパム鎮静閾値（Diazepam sedation threshold, DST）の臨床応用に関する研究

概要

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In an attempt to investigate the clinical applicability of the psychophysiological method to analyze the anxiety level, a test designated as Diazepam sedation threshold (DST) was devised and studies were carried out on its clinical applications. The results obtained are as follows ; 1. Appropriately diluted diazepam solution was injected intravenously at a constant rate of 2.5 m? per minutes, until the stage of slight sleep was noticed clinically and from EEG signs. The DST was defined as the amount of diazepam (mg/kg) required for the subject to fall asleep (little response to verbal stimulation), and the optimum diazepam dosage for the test was determined as 0.05 mg/kg/min. The measurement was highly reproducible and hardly showed any influences on the respiratory and cardiac functions. 2. As compared with the results obtained by amytal sleep threshold by Shagass, a significant correlation was observed between those of DST in patients with psychosomatic disorders (r=0.89, P<0.01). The influences of diazepam, amytal and chlorpromazine on DST could not be obtained. 3. The mean DST of 28 control subjects was 0.31 ± 0.08 mg/kg and the normal range was 0.15～0.47 mg/kg (mean ± 2S.D.). 31% of 58 cases with psychosomatic disorders and 83% of 18 cases with anxiety neurosis showed values above the normal range. There was a significant correlation between DST and Taylor-MAS in afflicted subjects (r=0.63, P<0.01), however it was scarcely observed in normal subjects. 4. By applying DST in practical use for interviews, psychosocial factors such as sexual trouble and latent hostilities which could not be clarified by ordinary interviews, were revealed. From the above results, the clinical applicability of the DST was discussed with the findings of anxiety and psychological tension of the patients with psychosomatic disorders.
札幌医科大学の論文
1978-04-01

ジアゼパム鎮静閾値（Diazepam sedation threshold, DST）の臨床応用に関する研究

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概要

札幌医科大学 | 論文

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