非小細胞肺癌における血清DNAを用いたマイクロサテライト変異の検討

概要

論文の詳細を見る
Recent studies indicate that soluble tumor DNA and microsatellite alterations have been identified in the peripheral blood of small cell lung cancer patients. There is a possibility that these might be useful for preoperative diagnosis, deciding on treatment strategy and postoperative evaluation as a new biomarker to detect genetic alterations originating from primary cancerous lesions in the peripheral blood of non-small cell lung cancer patients. The purpose of this study was to determine whether genetic alterations in resected cancer tissue could be identified in the preoperative peripheral serum by microsatellite DNA analysis. Our preliminary data, however, showed that no microsatellite alterations in tumor DNA could be found in the preoperative serum DNA of non-small cell lung cancer patients.
信州医学会の論文
1999-12-10