Prognostic Factors of 10-Year Survivors after Initial Treatmentfor Hepatocellular Carcinoma, Determined in 713 Japanese Patientsin Relation to Indication of Liver Transplantation.

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Purpose: To clarify the prognostic factors for long-term survival by studying the clinical factors of 10-year survivors afterinitial treatment for hepatocellular carcinoma (HCC).Methods: 713 Japanese patients who had received over 10 year’s observation after initial treatment for HCC were selected.Differences in clinical factors between 10-year survivors and the remainder were studied. The multiple logistic regressionmodel was used for multivariate analysis.Results: Significant differences were noted between the groups in age, tumor number, vascular involvement, concordanceof Milan Criteria (MC), Japanese tumor-node-metastasis stage, Child-Pugh stage (CP), HCV infection, serum α-fetoproteinlevel, and modality of initial treatment. Multivariate analysis showed that older age, out of MC, CP-B or -C, and initiallytreated other than by hepatectomy were independent risk factors for 10-year survival. If patients were within MC and CP-A,the overall 10-year survival rate of those initially treated by hepatectomy was 71%, and 49% for those with HCV infection.Conclusions: Younger patients with initial HCC within MC and CP-A can expect long-term survival, if surgicallyresectable. Hepatectomy should be considered especially to HCC patients with HCV infection, if in these categories.