A comparison of diagnostic tools for Sjögren syndrome, with emphasis on sialography, histopathology, and ultrasonography

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Objective. The present study examined the reliability and correlation of sialography, salivary gland biopsy, and ultrasonography for Sjögren's syndrome (SS), and evaluated the usefulness of ultrasonography as a diagnostic tool for SS in comparison with sialography and histopathology. Methods. Seventy-three patients who underwent sialography, ultrasonography, and salivary gland biopsy were included in this study. The study evaluated the diagnostic reliability and correlation of each kind of examination with SS. Results. There was a statistically significant difference in the sensitivities of sialography and histopathology, in the specificities of sialography and ultrasonography, and in the accuracies of sialography and both of ultrasonography and histopathology. The correlation coefficient (r) between sialography and ultrasonography was significantly higher than the others and indicated a good correlation. Conclusions. Ultrasonography can be used as a diagnostic tool for SS with its advantage of non-invasiveness and facility.