胃潰瘍治癒過程における神経細胞接着分子(NCAM)の発現

概要

論文の詳細を見る
Neural cell adhesion molecule (NCAM) is a glycoprotein, which belongs to the immunoglobulin superfamily and functions as homophilic adhesion molecule and is considered to play an important role in cell formation and tissue structure. NCAM is mainly expressed on neurogenic cells, myogenic cells and NK cells, but there is no report that NCAM is expressed on the gastric mucosal epithelium. In this study, we investigated the expression of NCAM in the healing process of human gastric ulcer and rat acetic acid induced ulcer with immunohistological methods, the reverse transcriptase-polymerase chain reaction (RT-PCR) and Southern blot analysis. The results were as follows. 1) Immunohistologically NCAM was expressed in the gastric mucosal epithelium in human gastric ulcer and rat acetic acid induced ulcer in the healing stage. 2) NCAM was also expressed in the fraction of gastric mucosa adjacent to the ulcer by dot blot analysis. 3) RT-PCR and Southern blot analysis revealed that NCAM mRNA was expressed in the gastric mucosa in the healing stage and it contained a transmembrane domain, suggesting that it plays an important role in mucosal repair of gastric ulcer.
札幌医科大学の論文
1995-10-01