Biliary Glycoprotein I(BGP I)の発現 ―肝細胞癌を中心に―

概要

論文の詳細を見る
Molecular biological and immunohistochemical analyses of the expression of biliary glycoprotein I (BGP I) were performed in hepatocellular carcinomas. The following results were obtained : 1. BGP I mRNA was expressed in a variety of epithelial tumor cell lines. 2. There was no significant difference between cancerous and non-cancerous colon tissues in the expression of BGP I mRNA, which was distinct from that of NCA mRNA. 3. BGP I mRNA was revealed in hepatocytes and hepatocellular carcinomas by Northern blot and in situ hybridization analyses. 4. An immunohistochemical study was carried out using anti-CEA peptide MoAb P1-255 which had been shown to be crossreactive with BGP I, since CEA and NCA mRNAs were not detected in the liver. The cytoplasm and bile canaliculi were positive for P1-255 in non-cancerous tissues. 5. In hepatocellular carcinomas the expression of BGP I tended to decrease with the level of differentiation. In conclusion, it was revealed at the levels of mRNA and protein that BGP I is expressed in the hepatocytes and hepatocellular carcinomas.
札幌医科大学の論文
1993-04-01