AIDSウイルス感染個体におけるCD8陽性細胞の役割に関する研究
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概要
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The roles and characteristics of CD8+ lymphocytes of naturally HlV-l-infected humans and SIVmac-infected rhesus monkeys were investigated. In this series of experiments, we showed that CD8+ lymphocytes, with the phenotype of CTL, inhibit virus replication in autologous CD4+ cells in vitro. The virus inhibitory cell population requires time for generation. The cells do not express NK- associated antigens, and are thought to be class I MHC-restricted. Their surface phenotype is CD29 rather than CD45R. Their virus inhibitory function requires cell-to-cell contact via the CD11a molecule and some of the epitopes of the CD8 molecule. Interestingly, in the course of our study, we revealed that CD8+CD4～ lymphocyte lines established from AIDS virus-infected individuals not only showed CTL activity, but also could harbor AIDS virus.
- 札幌医科大学の論文
- 1991-06-01
札幌医科大学 | 論文
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