子宮頚癌組織ならびに所属リソパ節におけるT細胞の免疫組織学的検討
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概要
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We identified T cell and T cell subsets in cancer tissues obtained from 74 cases of uterine cervical cancer and regional lymph nodes by using immunohistochemistry. The following results were obtained. (1) There was a difference in the pattern of T cells between squamous cell carcinoma and adenocarcinoma, that is, T cells infiltrating cancer tissues densely touched the foci in squamous cell carcinoma while only sparsely in adenocarcinoma. In general, T cell infiltration in adenocarcinoma was less than that in squamous cell carcinoma. (2) CD8 positive cells were found among the cancer cells in the cancerous foci. (3) Although a large number of T cells were recognized in stage O to stage IIb, there were few in stage IIIb. There was a predominance of CD8, which existed much more commonly than CD4. (4) The CD4/8 ratio in lymph nodes with metastasis was significantly lower than in those without metastasis. (5) Cases with a large number of infiltrating T cells tended not to have lymph node metastasis. In particular, lymph nodes with CD8-predominance had significantly less lymph node metastasis compared to those with CD4-predominance. (6) A small number of IL-2R positive cells were identified in cancer tissues and lymph nodes, being related to the number of infiltrating T cells. (7) Patients with MHC class I had a large number of infiltrating T cells and CD8 predominance in most cases. (8) Five-year survival in groups with heavy and moderate infiltration was 100%, while that in groups with slight and extremely slight infiltration was 86.7% and 50.0%, respectively. The five- year survival rates for cases of CD8-dominance, equality and CD4-dominance were 100%, 83.3% and 71.4%, respectively. As mentioned above, we recognized in cancerous foci and lymph nodes that differences in histologic types and clinical stage caused an alteration of the pattern of the T cell and its subsets, thus confirming the existence of an immune response in cancer tissues. Finally, we determined the effect of T cell infiltration on prognosis and found that the number of T cells in cancer tissue was one of the factors that influenced the prognosis.
- 札幌医科大学の論文
- 1990-12-01
札幌医科大学 | 論文
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