進行癌患者に対するCyclophosphamide併用養子免疫療法の検討
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概要
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Adoptive immunotherapy with lymphokine activated killer (LAK) cells and interleukin 2 (IL-2) is a cancer therapy that was originally reported by Rosenberg et al. In Japan, however, no promising efficacy has been obtained because of the limitation of dosage of IL-2 and LAK cells in the approved trials. For improving the efficacy of adoptive immunotherapy, we framed a new protocol for the combination of IL-2 and LAK cells, with cyclophosphamide (CY) because CY causes immunological activity to increase in small doses. This study compared the clinical efficacy of IL-2 plus CY plus LAK therapy (IL-2+CY+LAK), IL-2 monotherapy, IL-2 plus LAK therapy and IL-2 plus CY therapy. There were 7, 6, 9 and 5 cases in the IL-2+CY+LAK group, IL-2 monotherapy group, IL-2 plus LAK therapy group and IL-2 plus CY therapy group, respectively. In terms of high clinical response, there was at least a partial response (PR) in the IL-2+CY+LAK group with 28.6%, as there was in the IL-2 plus CY therapy group with 20%, in comparison with the IL-2 monotherapy group with 0% and the IL-2 plus LAK therapy group with 0%. The rate for minor response (MR) or better was evidently high in the IL-2+CY+LAK group with 42.9% in comparison with other therapy groups. As for the changes of surface markers of lymphocytes in each therapy group, a significant increase of CD8 positive cells and a significant decrease of the CD 4/8 ratio were noted in the IL-2+CY+LAK group. In addition, significant cytotoxicities against Daudi cells both by LAK cells and by freshly-obtained lymphocytes were observed. These findings suggest that the 3-drug (IL-2, CY and LAK cells) combined therapy may have increased the effect of exogenous LAK cells and also induced endogenous LAK cells, resulting in the enhancement of antitumor efficacy. In conclusion, this 3-drug combined therapy would be useful in the treatment of malignant tumors.
- 札幌医科大学の論文
- 1990-10-01
札幌医科大学 | 論文
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