Local Immunotherapy of Mouse Mammary Carcinoma by Hetorologous Antibodies Reactive Aginst Serum Alpha-Globulin Components

概要

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Antibodies raised against the whole alpha-globulin fraction of mice serum killed mouse mammary carcinoma tumor cells and normal spleen cells by icubation and abrogated the growth of transplanted mammary carcinoma by local injection at the tumor site. Immunoelectrophoreticaly, 3-5 different components could be detected in the isolated serum fraction and all of them cross reacted in the immunodiffusion analyses with components included in serum-free tumor or normal crude mouse tissue extracts. Local treatment of the tumor by heterologous antibodies raised against the serum alpha-globulin or the tissue alpha-globulin equivalent was effective at the early stages of the disease development without systemic adverse reactions.
札幌医科大学の論文