Primary Gastric T Cell Lymphoma with Epstein-Barr Virus Infection.

概要

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Primary gastric T cell malignant lymphomas are very rare. Here we report a case of primary gastric T cell lymphoma infected with Epstein-Barr virus (EBV). Histologic and immunohistologic features, positive for CD45RO/UCHL1 and negative for CD20/L26, showed this tumor to be a diffuse, large cell type, malignant lymphoma with a T cell phenotype. Genotypic analysis by the South-ern blot method, demonstrating T cell receptor gene rearrangement and a germ-line configuration of the immunoglobulin gene, also supported the T cell origin of this tumor. EBV DNA was detected by polymerase chain reaction and in situ hybridization against EBER1 demonstrated that EBV was located in the lymphoma cells. This is the first Japanese case report of primary gastric malig-nant lymphoma of T cell origin infected with EBV.
札幌医科大学の論文
1996-00-00