Ovarian Sertoli-Leydig Cell Tumor with High Serum Level of alpha-Fetoprotein

概要

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A case of an ovarian Sertoli Leydig cell tumor (SLCT) associated with ele-vated serum alpha-fetoprotein (AFP) levels occurred in a 16-year-old girl. She had no signs of virilization or defeminization at the operation. In the abdominal cavity, a large and well demarcated tumor had replaced the right ovary. After the surgical removal of the tumor, the serum level of AFP decreased to within the normal limits. Microscopic examination of the tumor revealed intermediately differentiated SLCT with a retiform component. Immunohistochemical studies demonstrated the immunoreactivity of AFP in Leydig cells and Sertoli cells. The mechanisms of AFP production by SLCT were discussed here along with a review of the literature.
札幌医科大学の論文
1996-00-00