Case Report : Multiple myeloma, IgAχ type, accompanying crystal-storing myeloma cells and macrophages

概要

論文の詳細を見る
We report a 75-year-old male with multiple myeloma, IgAχ , accompanying crystal-storing myeloma cells and macrophages in the bone marrow. Bone mar-row aspiration showed increased plasmacytoid cells (15.6%) with around 20 to 50 of pink-staining rod crystals in their cytoplasm. These inclusions were stained by May-Giemsa and acid phosphatase, but not by peroxidase, esterase, periodic acid Sciff, alkaline phosphatase, direct fast scarlet and thioflavine-T. Large macrophages containing numerous cytoplasmic crystalline rods were also found at 0.6%. Cytochemical findings of the inclusions were the same as those of myeloma cells. Immunohistochemical staining of the inclusions with anti-α and anti-χ antibodies was negative. Electron-microscopic studies demonstrated clear hexagonal crystalline structures in myeloma cells, part of which appeared to be bound by a single smooth membrane. These data suggest that the cytoplasmic inclusions may be related with lysosomal granules.
札幌医科大学の論文
1994-00-00