Heat Shock Protein 27 Serves as a Differentiation Marker in Oral Squamous Cell Carcinoma

概要

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We examined the expression of heat shock protein (HSP) 27 in normal oral squamous epithelium and oral squamous cell carcinoma with an immunohisto-chemical method and compared the results wiht the expressions of proliferation cell nuclear antigen (PCNA), and transglutaminase (TG). HPS27 was expres-sed in good correlation with the expression of TG in the differentiated and dyskeratotic cells, expect for the completely keratinized cells composing the can-cer pearl of squamous cell carcinoma. HSP27 expression was very low in the cells positive for PCNA. These results suggest that HSP 27 is useful as a differentiation marker in squamous cell carcinoma.
札幌医科大学の論文
1994-00-00