Histopathological Study on Dysbaric Osteonecrosis (DON) in Tibiae of Sheep with a Hyperbaric Exposure

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概要

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• Previously we proposed a hypothesis that activation of blood coagulability in the intraosseous bloodvessels contr ibutes impor tantly to produce decompression sickness (DCS) including dysbaric osteonecrosis(DON) after a hyperbar ic exposure. This paper presents evidence suppor ting this hypothesis. Crossbred,adult, female sheep were exposed to a three-hour exposure at 2.8-3.2 atm abs, using an experimental hyperbar ic chamber . They showed signs of bends in various legs soon after the exposure.Eight weeks after decompression insult, more or less marked and extensive pathologic findings of thebone mar row tissue wer e noted at the time of autopsy in their tibiae. In thr ee tibiae of seven exper imental・・sheep, a wide spread necrosis was found in the bone mar row, particular ly in the upper half of the shaft. ・・In one of them, the large branches including the main ascending branch of the intraosseous nutr ientar tery wer e obliter ated by organized thrombi at a little above the middle por tion of the shaft of the r ighttibia. This ar ter ial lesion seemed closely r elated to a widespr ead necrosis of the bone mar row of upperhalf of the shaft. Another conspicuous finding was formation of cutting cones, a repair process, observedin the cor tical compact bone. Through formation of cutting cones, blood supply of the cor tical bone recoveredfrom the per iosteum resulting in an active organization of necrotic bone mar row, where activeformation of woven bone was observed. These suggest that provocative hyperbar ic exposure can causear ter ial thrombosis to produce ear ly stage of necrosis of the bone tissues, and the subsequent repair processescan exagger ate the featur es of DON.

• 鹿児島大学多島圏研究センターの論文

著者

• TAYA Yasushi

  Undersea Science and Technology Department. Japan Marine Science and Technology Center

• Kitano M

  Kagoshima Univ. Dental School Kagoshima Jpn

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• Histopathological Study on Dysbaric Osteonecrosis (DON) in Tibiae of Sheep with a Hyperbaric Exposure

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