鰓弓神経節の形成に異常を示す変異体nepの原因遺伝子クローニング

概要

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In vertebrates, epibranchial ganglia have pivotal roles for maintenance of the inner environment. In our past study, we identified one line of mutant, named non-epibranchial (nep), which lack all epibranchial ganglia at two days after fertilization with earlier molecular markers relatively unaffected. This suggests that responsible gene, nep, disrupted in this mutant is required for later differentiation or survival of these ganglia. Increasing cell death around branchial region after formation of the ganglia in nep homozygous mutant embryo also supports this idea. Currently, we identified a strong candidate of nep gene on the linkage group 20 (LG20) and are examining its function during epibranchial ganglia development.
埼玉大学総合研究機構地域共同研究センター産学連携推進部門の論文
2005-00-00